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KMID : 0614020020170010068
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.68 ~ p.77
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Preparation and Evaluation of Dermal Delivery System of the Local Anesthetics
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Cho Mi-Hyun
Kim Dong-Woo
Park Yong-Keun
Jee Ung-Kil
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Abstract
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For the dermal drug delivery system of local anesthetics (lidocaine HCl, and benzocaine), the drugs were formulated as hydrogel. The experiments of the formulation design were summarized as below, the lipid-water partition coefficients of drugs were evaluated and the vehicles with different concentrations of ethanol, glycerine and various enhancers were prepared for the formulation of hydrogel. After using these vehicles, hydrogel were formulated. The gelling agent was poloxamer 407. The resulting preparations were evaluated using in vitro drug permeation and drug accumulation in hairless mouse skin. The preparations were also evaluated by their viscosity and stability, In addition, using the tail-flick analgesia test, analgesic activity of the gel was compared with that of commercial cream.
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KEYWORD
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Lidocaine HCl, benzocaine, dermal drug delivery system, poloxamer 407, hydrogel
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